N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling

N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling

Abstract Signalling through TNFR1 modulates proinflammatory gene transcription and programmed cell death, and its impairment causes autoimmune diseases and cancer. NEDD4-binding protein 1 (N4BP1) is a critical suppressor of proinflammatory cytokine production that acts as a regulator of innate immun...

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Bibliographic Details
Main Authors: Katarzyna W. Kliza, Wei Song, Irene Pinzuti, Simone Schaubeck, Simone Kunzelmann, David Kuntin, Arianna Fornili, Alessandro Pandini, Kay Hofmann, James A. Garnett, Benjamin Stieglitz, Koraljka Husnjak
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-01913-8

Internet

https://doi.org/10.1038/s41420-024-01913-8

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