Organization of DNA Replication Origin Firing in <i>Xenopus</i> Egg Extracts: The Role of Intra-S Checkpoint

Organization of DNA Replication Origin Firing in <i>Xenopus</i> Egg Extracts: The Role of Intra-S Checkpoint

During cell division, the duplication of the genome starts at multiple positions called replication origins. Origin firing requires the interaction of rate-limiting factors with potential origins during the S(ynthesis)-phase of the cell cycle. Origins fire as synchronous clusters which is proposed t...

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Bibliographic Details
Main Authors: Diletta Ciardo, Olivier Haccard, Hemalatha Narassimprakash, Jean-Michel Arbona, Olivier Hyrien, Benjamin Audit, Kathrin Marheineke, Arach Goldar
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Genes
Subjects:
DNA replication
checkpoint
mathematical modelling
minimal model
origin firing
Online Access:https://www.mdpi.com/2073-4425/12/8/1224

Internet

https://www.mdpi.com/2073-4425/12/8/1224

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