Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as...

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Bibliographic Details
Main Authors: Jing-Ping Liou, Jang-Yang Chang, Chih-Ying Nien, Cheng-Chih Hsieh, Chi-Yen Chang, Ching-Chuan Kuo, Hsueh-Yun Lee
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Molecules
Subjects:
combretastatin analogs
multidrug-resistant
trimethoxyquinolines
antiproliferative activity
Online Access:http://www.mdpi.com/1420-3049/16/3/2274/

Internet

http://www.mdpi.com/1420-3049/16/3/2274/

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