Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents
A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/3/2274/ |
| _version_ | 1811250534460424192 |
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| author | Jing-Ping Liou Jang-Yang Chang Chih-Ying Nien Cheng-Chih Hsieh Chi-Yen Chang Ching-Chuan Kuo Hsueh-Yun Lee |
| author_facet | Jing-Ping Liou Jang-Yang Chang Chih-Ying Nien Cheng-Chih Hsieh Chi-Yen Chang Ching-Chuan Kuo Hsueh-Yun Lee |
| author_sort | Jing-Ping Liou |
| collection | DOAJ |
| description | A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively. |
| first_indexed | 2024-04-12T16:06:33Z |
| format | Article |
| id | doaj.art-c5757fd4e4e44640934a2f3f6505fcb8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T16:06:33Z |
| publishDate | 2011-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c5757fd4e4e44640934a2f3f6505fcb82022-12-22T03:26:03ZengMDPI AGMolecules1420-30492011-03-011632274228410.3390/molecules16032274Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer AgentsJing-Ping LiouJang-Yang ChangChih-Ying NienCheng-Chih HsiehChi-Yen ChangChing-Chuan KuoHsueh-Yun LeeA series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.http://www.mdpi.com/1420-3049/16/3/2274/combretastatin analogsmultidrug-resistanttrimethoxyquinolinesantiproliferative activity |
| spellingShingle | Jing-Ping Liou Jang-Yang Chang Chih-Ying Nien Cheng-Chih Hsieh Chi-Yen Chang Ching-Chuan Kuo Hsueh-Yun Lee Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents Molecules combretastatin analogs multidrug-resistant trimethoxyquinolines antiproliferative activity |
| title | Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents |
| title_full | Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents |
| title_fullStr | Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents |
| title_full_unstemmed | Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents |
| title_short | Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents |
| title_sort | synthesis and biological evaluation of 4 aroyl 6 7 8 trimethoxyquinolines as a novel class of anticancer agents |
| topic | combretastatin analogs multidrug-resistant trimethoxyquinolines antiproliferative activity |
| url | http://www.mdpi.com/1420-3049/16/3/2274/ |
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