Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex

Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex

Neuroinflammation is tightly associated with onset of depression. The nuclear receptor related 1 protein (Nurr1, also called Nr4a2), its roles in dopaminergic neurons is well understood, which can alleviate inflammation. Nevertheless, potential effects of Nr4a2 on neuroinflammation associated with d...

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Bibliographic Details
Main Authors: Yong He, Yue Wang, Heming Yu, Yu Tian, Xiangyu Chen, Chong Chen, Yikun Ren, Zhi Chen, Yi Ren, Xue Gong, Ke Cheng, Xiaolei Liu, Lianmei Zhong, Yi Guo, Peng Xie
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Pharmacological Research
Subjects:
Neuroinflammation
Depression
Anterior cingulate cortex
Nr4a2
LPS
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823000737

Internet

http://www.sciencedirect.com/science/article/pii/S1043661823000737

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