IL-15 deficiency alleviates steroid-induced osteonecrosis of the femoral head by impact osteoclasts via RANKL-RANK-OPG system

IL-15 deficiency alleviates steroid-induced osteonecrosis of the femoral head by impact osteoclasts via RANKL-RANK-OPG system

Abstract Background Whether IL-15 is involved in the development of steroid-induced osteonecrosis of the femoral head (ONFH) is investigated. Methods C57BL/6 J and l15−/−mice were injected with methylprednisolone to induce wide type osteonecrosis (WT ON) and IL-15 deficiency osteonecrosis (IL-15−/−...

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Bibliographic Details
Main Authors: Zubin Zhou, Yiwei Lin, Chenhao Pan, Nan Wang, Lihui Zhou, Haojie Shan, Youshui Gao, Xiaowei Yu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Immunity & Ageing
Subjects:
IL-15
Osteonecrosis
RANKL
RANK
OPG
Online Access:http://link.springer.com/article/10.1186/s12979-020-00190-0

Internet

http://link.springer.com/article/10.1186/s12979-020-00190-0

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