RCAN1-mediated calcineurin inhibition as a target for cancer therapy
Abstract Cancer is the leading cause of mortality worldwide. Regulator of calcineurin 1 (RCAN1), as a patent endogenous inhibitor of calcineurin, plays crucial roles in the pathogenesis of cancers. Except for hypopharyngeal and laryngopharynx cancer, high expression of RCAN1 inhibits tumor progressi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-022-00492-7 |
| _version_ | 1811242322341396480 |
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| author | Mengyi Lao Xiaozhen Zhang Hanshen Yang Xueli Bai Tingbo Liang |
| author_facet | Mengyi Lao Xiaozhen Zhang Hanshen Yang Xueli Bai Tingbo Liang |
| author_sort | Mengyi Lao |
| collection | DOAJ |
| description | Abstract Cancer is the leading cause of mortality worldwide. Regulator of calcineurin 1 (RCAN1), as a patent endogenous inhibitor of calcineurin, plays crucial roles in the pathogenesis of cancers. Except for hypopharyngeal and laryngopharynx cancer, high expression of RCAN1 inhibits tumor progression. Molecular antitumor functions of RCAN1 are largely dependent on calcineurin. In this review, we highlight current research on RCAN1 characteristics, and the interaction between RCAN1 and calcineurin. Moreover, the dysregulation of RCAN1 in various cancers is reviewed, and the potential of targeting RCAN1 as a new therapeutic approach is discussed. |
| first_indexed | 2024-04-12T13:48:43Z |
| format | Article |
| id | doaj.art-c57d229ecdf145298b9594363c2018fc |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-04-12T13:48:43Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-c57d229ecdf145298b9594363c2018fc2022-12-22T03:30:35ZengBMCMolecular Medicine1076-15511528-36582022-06-0128111910.1186/s10020-022-00492-7RCAN1-mediated calcineurin inhibition as a target for cancer therapyMengyi Lao0Xiaozhen Zhang1Hanshen Yang2Xueli Bai3Tingbo Liang4Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract Cancer is the leading cause of mortality worldwide. Regulator of calcineurin 1 (RCAN1), as a patent endogenous inhibitor of calcineurin, plays crucial roles in the pathogenesis of cancers. Except for hypopharyngeal and laryngopharynx cancer, high expression of RCAN1 inhibits tumor progression. Molecular antitumor functions of RCAN1 are largely dependent on calcineurin. In this review, we highlight current research on RCAN1 characteristics, and the interaction between RCAN1 and calcineurin. Moreover, the dysregulation of RCAN1 in various cancers is reviewed, and the potential of targeting RCAN1 as a new therapeutic approach is discussed.https://doi.org/10.1186/s10020-022-00492-7RCAN1CalcineurinCancer therapy |
| spellingShingle | Mengyi Lao Xiaozhen Zhang Hanshen Yang Xueli Bai Tingbo Liang RCAN1-mediated calcineurin inhibition as a target for cancer therapy Molecular Medicine RCAN1 Calcineurin Cancer therapy |
| title | RCAN1-mediated calcineurin inhibition as a target for cancer therapy |
| title_full | RCAN1-mediated calcineurin inhibition as a target for cancer therapy |
| title_fullStr | RCAN1-mediated calcineurin inhibition as a target for cancer therapy |
| title_full_unstemmed | RCAN1-mediated calcineurin inhibition as a target for cancer therapy |
| title_short | RCAN1-mediated calcineurin inhibition as a target for cancer therapy |
| title_sort | rcan1 mediated calcineurin inhibition as a target for cancer therapy |
| topic | RCAN1 Calcineurin Cancer therapy |
| url | https://doi.org/10.1186/s10020-022-00492-7 |
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