Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells

Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells

Synaptic vesicle fusion is mediated by an assembly of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs), composed of syntaxin 1, soluble NSF-attachment protein (SNAP)-25, and synaptobrevin-2/VAMP-2. Previous studies have suggested that over-exposure to manganese...

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Bibliographic Details
Main Authors: Can Wang, Zhuo Ma, Dong-Ying Yan, Chang Liu, Yu Deng, Wei Liu, Zhao-Fa Xu, Bin Xu
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cells
Subjects:
manganese
SNARE complex
alpha-synuclein
synaptic vesicle fusion
neurotoxicity
Online Access:https://www.mdpi.com/2073-4409/7/12/258

Internet

https://www.mdpi.com/2073-4409/7/12/258

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