Whole-cell modeling of E. coli colonies enables quantification of single-cell heterogeneity in antibiotic responses.

Whole-cell modeling of E. coli colonies enables quantification of single-cell heterogeneity in antibiotic responses.

Antibiotic resistance poses mounting risks to human health, as current antibiotics are losing efficacy against increasingly resistant pathogenic bacteria. Of particular concern is the emergence of multidrug-resistant strains, which has been rapid among Gram-negative bacteria such as Escherichia coli...

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Bibliographic Details
Main Authors: Christopher J Skalnik, Sean Y Cheah, Mica Y Yang, Mattheus B Wolff, Ryan K Spangler, Lee Talman, Jerry H Morrison, Shayn M Peirce, Eran Agmon, Markus W Covert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1011232

Internet

https://doi.org/10.1371/journal.pcbi.1011232

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