A multifaceted review of monosodium glutamate effects on human health and its natural remedies
Monosodium glutamate is a non-essential amino acid in the human body that has been widely used as a food additive since 1909 due to its unique umami taste. Typical food containing monosodium glutamate include tomatoes, yeast extracts, fermented soy products, and cheese. After entering the human body...
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| Format: | Article |
| Language: | English |
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Maximum Academic Press
2023-02-01
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| Series: | Food Materials Research |
| Subjects: | |
| Online Access: | https://www.maxapress.com/article/doi/10.48130/FMR-2023-0016 |
| _version_ | 1797293258089431040 |
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| author | Li Yang Yongchao Gao Jupeng Gong Liang Peng Hesham R. El-Seedi Mohamed A. Farag Yonghua Zhao Jianbo Xiao |
| author_facet | Li Yang Yongchao Gao Jupeng Gong Liang Peng Hesham R. El-Seedi Mohamed A. Farag Yonghua Zhao Jianbo Xiao |
| author_sort | Li Yang |
| collection | DOAJ |
| description | Monosodium glutamate is a non-essential amino acid in the human body that has been widely used as a food additive since 1909 due to its unique umami taste. Typical food containing monosodium glutamate include tomatoes, yeast extracts, fermented soy products, and cheese. After entering the human body, it is mainly absorbed in the small intestine by passive diffusion. Subsequent binding to TAS1R1-TAS1R3 promotes the release of intracellular calcium that ultimately activates the brain’s taste center, recognized as an umami taste of monosodium glutamate. However, more and more preclinical and clinical data indicates that monosodium glutamate exerts adverse effects on humans, including metabolic syndrome, neurotoxicity, renal toxicity, cardiovascular disease, infertility and fetal underdevelopment, cancer, immune malfunction and so on. In addition, it has been found that medicinal plants and nutraceuticals could mitigate or treat the adverse effects of monosodium glutamate adverse. Taken together, we hope to raise the correct awareness of monosodium glutamate and improve the understanding of monosodium glutamate quality approaches to maximize their use. |
| first_indexed | 2024-03-07T20:10:15Z |
| format | Article |
| id | doaj.art-c5894c7a873946e0a7d2cabd0ffd58b9 |
| institution | Directory Open Access Journal |
| issn | 2771-4683 |
| language | English |
| last_indexed | 2024-03-07T20:10:15Z |
| publishDate | 2023-02-01 |
| publisher | Maximum Academic Press |
| record_format | Article |
| series | Food Materials Research |
| spelling | doaj.art-c5894c7a873946e0a7d2cabd0ffd58b92024-02-28T01:36:14ZengMaximum Academic PressFood Materials Research2771-46832023-02-013111310.48130/FMR-2023-0016FMR-2023-0016A multifaceted review of monosodium glutamate effects on human health and its natural remediesLi Yang0Yongchao Gao1Jupeng Gong2Liang Peng3Hesham R. El-Seedi4Mohamed A. Farag5Yonghua Zhao6Jianbo Xiao7Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinsese Medicine, University of Macau, Macao 999078, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, ChinaPharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Box 591, 751 24, Uppsala, SwedenDepartment of Food Science and Engineering, Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, ChinaPharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini st., P.B. 11562, Cairo, Egypt.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinsese Medicine, University of Macau, Macao 999078, ChinaUniversidade de Vigo, Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Sciences, 32004, Ourense, SpainMonosodium glutamate is a non-essential amino acid in the human body that has been widely used as a food additive since 1909 due to its unique umami taste. Typical food containing monosodium glutamate include tomatoes, yeast extracts, fermented soy products, and cheese. After entering the human body, it is mainly absorbed in the small intestine by passive diffusion. Subsequent binding to TAS1R1-TAS1R3 promotes the release of intracellular calcium that ultimately activates the brain’s taste center, recognized as an umami taste of monosodium glutamate. However, more and more preclinical and clinical data indicates that monosodium glutamate exerts adverse effects on humans, including metabolic syndrome, neurotoxicity, renal toxicity, cardiovascular disease, infertility and fetal underdevelopment, cancer, immune malfunction and so on. In addition, it has been found that medicinal plants and nutraceuticals could mitigate or treat the adverse effects of monosodium glutamate adverse. Taken together, we hope to raise the correct awareness of monosodium glutamate and improve the understanding of monosodium glutamate quality approaches to maximize their use.https://www.maxapress.com/article/doi/10.48130/FMR-2023-0016monosodium glutamatehealthsafetytoxicitynatural products |
| spellingShingle | Li Yang Yongchao Gao Jupeng Gong Liang Peng Hesham R. El-Seedi Mohamed A. Farag Yonghua Zhao Jianbo Xiao A multifaceted review of monosodium glutamate effects on human health and its natural remedies Food Materials Research monosodium glutamate health safety toxicity natural products |
| title | A multifaceted review of monosodium glutamate effects on human health and its natural remedies |
| title_full | A multifaceted review of monosodium glutamate effects on human health and its natural remedies |
| title_fullStr | A multifaceted review of monosodium glutamate effects on human health and its natural remedies |
| title_full_unstemmed | A multifaceted review of monosodium glutamate effects on human health and its natural remedies |
| title_short | A multifaceted review of monosodium glutamate effects on human health and its natural remedies |
| title_sort | multifaceted review of monosodium glutamate effects on human health and its natural remedies |
| topic | monosodium glutamate health safety toxicity natural products |
| url | https://www.maxapress.com/article/doi/10.48130/FMR-2023-0016 |
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