STEAP3 promotes cancer cell proliferation by facilitating nuclear trafficking of EGFR to enhance RAC1-ERK-STAT3 signaling in hepatocellular carcinoma

Abstract STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is still unknown. In the present study, we fo...

Full description

Bibliographic Details
Main Authors: Li-Li Wang, Jie Luo, Zhang-Hai He, Ye-Qing Liu, Hai-Gang Li, Dan Xie, Mu-Yan Cai
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04329-9