Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia

Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia

Infantile neuronal ceroid lipofuscinosis (INCL), the most severe form of neuronal ceroid lipofuscinoses, is caused by mutations in the lysosomal enzyme palmitoyl protein thioesterase 1 (PPT1). Typical symptoms of this disease include progressive psychomotor developmental retardation, visual failure,...

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Bibliographic Details
Main Authors: Xusheng Zhang, Mengting Wang, Bingyan Feng, Qiuyu Zhang, Jia Tong, Mingyong Wang, Chengbiao Lu, Shiyong Peng
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
seizures
microglia
A 438079
PPT1 KI mice
hippocampus
Online Access:https://www.mdpi.com/1422-0067/23/10/5586

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https://www.mdpi.com/1422-0067/23/10/5586

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