Mexiletine Differentially Restores the Trafficking Defects Caused by Two Brugada Syndrome Mutations

Mexiletine Differentially Restores the Trafficking Defects Caused by Two Brugada Syndrome Mutations

The human cardiac sodium channel Nav1.5 encoded by the SCN5A gene plays a critical role in cardiac excitability and the propagation of action potentials. Nav1.5 dysfunctions due to mutations cause cardiac diseases such as the LQT3 form of long QT syndrome, conduction disorders, and Brugada syndrome...

Full description

Bibliographic Details
Main Authors: Adrien eMoreau, Dagmar I Keller, Hai eHuang, Véronique eFressart, Christian eSchmied, Quadiri eTimour, Mohamed eChahine
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-04-01
Series:Frontiers in Pharmacology
Subjects:
Brugada Syndrome
Mexiletine
Sodium Channels
Ventricular Fibrillation
cardiac arrhythmias
Nav1.5
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00062/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00062/full

Similar Items