Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning

Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning

Conditioning chemotherapy is used to deplete hematopoietic stem cells in the recipient’s marrow, facilitating donor cell engraftment. Although effective, a major issue with chemotherapy is the systemic genotoxicity that increases the risk for secondary malignancies. Antibody conjugates targeting hem...

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Bibliographic Details
Main Authors: Meera A. Srikanthan, Olivier Humbert, Kevin G. Haworth, Christina Ironside, Yogendra S. Rajawat, Bruce R. Blazar, Rahul Palchaudhuri, Anthony E. Boitano, Michael P. Cooke, David T. Scadden, Hans-Peter Kiem
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
Fanconi anemia
Fanconi anemia gene therapy
non-genotoxic conditioning
saporin
CD117
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300267

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http://www.sciencedirect.com/science/article/pii/S2329050120300267

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