Pyrrolidine derivatives as α-amylase and α-glucosidase inhibitors: Design, synthesis, structure-activity relationship (SAR), docking studies and HSA binding

Pyrrolidine derivatives as α-amylase and α-glucosidase inhibitors: Design, synthesis, structure-activity relationship (SAR), docking studies and HSA binding

In our pursuit of developing effective inhibitors for the enzymes α-amylase and α-glucosidase, which play a crucial role in carbohydrate metabolism related to type-2 diabetes, we synthesized compounds featuring a pyrrolidine ring. The synthesis involved coupling N-Boc-proline with various aromatic a...

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Bibliographic Details
Main Authors: Aeyaz Ahmad Bhat, Nitin Tandon, Iqubal Singh
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
α-amylase
α-glucosidase
Antidiabetic activity
Diabetes mellitus
Pyrrolidine
Structure-activity relationship (SAR)
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024154758

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http://www.sciencedirect.com/science/article/pii/S2405844024154758

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