Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase

Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase

AbstractPhenethyl-based edelfosine-analogs with saturated, monounsaturated, or polyunsaturated alkoxy substituents on phenyl ring were designed as novel antitumor lipids modulating p38 MAPK. Evaluation of the synthesised compounds against nine panels of diverse cancer cells presented saturated and m...

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Bibliographic Details
Main Authors: Ahmed H. E. Hassan, Yeon Il Oh, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Md. Maqusood Alam, Sang-Eun Park, Kyung-Sook Chung, Kyung-Tae Lee, Yong Sup Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Antitumor lipids
Phospholipids
Cancer
p38 MAPK 
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2217695

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2217695

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