Structures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity

Structures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity

Abstract Prostaglandins and their receptors regulate various physiological processes. Carboprost, an analog of prostaglandin F2α and an agonist for the prostaglandin F2-alpha receptor (FP receptor), is clinically used to treat postpartum hemorrhage (PPH). However, off-target activation of closely re...

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Bibliographic Details
Main Authors: Xiuqing Lv, Kaixuan Gao, Jia Nie, Xin Zhang, Shuhao Zhang, Yinhang Ren, Xiaoou Sun, Qi Li, Jingrui Huang, Lijuan Liu, Xiaowen Zhang, Weishe Zhang, Xiangyu Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43922-8

Internet

https://doi.org/10.1038/s41467-023-43922-8

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