Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin‐Induced Heart Failure Through Resolution of Toll‐Like Receptor 2–Mediated Myocardial Inflammation

Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin‐Induced Heart Failure Through Resolution of Toll‐Like Receptor 2–Mediated Myocardial Inflammation

Background Heart failure (HF) is one of the most significant causes of morbidity and mortality for the cardiovascular risk population. We found previously that extracellular HSP70 (heat shock protein) is an important trigger in cardiac hypertrophy and fibrosis, which are associated with the developm...

Full description

Bibliographic Details
Main Authors: Peng Liu, Hua‐Yan Bao, Cai‐Cai Jin, Ji‐Chao Zhou, Fang Hua, Ke Li, Xiao‐Xi Lv, Bing Cui, Zhuo‐Wei Hu, Xiao‐Wei Zhang
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac dysfunction
cardiac remodeling
damage‐associated molecular patterns
nuclear factor‐κB
toll‐like receptor
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.012338

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.012338

Similar Items