Exploiting Human NK Cells in Tumor Therapy

Exploiting Human NK Cells in Tumor Therapy

NK cells play an important role in the innate defenses against tumor growth and metastases. Human NK cell activation and function are regulated by an array of HLA class I-specific inhibitory receptors and activating receptors recognizing ligands expressed de novo on tumor or virus-infected cells. NK...

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Bibliographic Details
Main Authors: Paola Vacca, Gabriella Pietra, Nicola Tumino, Enrico Munari, Maria Cristina Mingari, Lorenzo Moretta
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
NK cells
inhibitory checkpoints
innate immunity
immunotherapy
anti-tumor therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03013/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03013/full

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