A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes

Protein arginine methyltransferases (PRMTs) play important roles in transcription, splicing, DNA damage repair, RNA biology, and cellular metabolism. Thus, PRMTs have been attractive targets for various diseases. In this study, we reported the design and synthesis of a potent pan-inhibitor for PRMTs...

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Bibliographic Details
Main Authors: Iredia D. Iyamu, Ayad A. Al-Hamashi, Rong Huang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/11/6/854