Regulation of Proinflammatory Molecules and Tissue Factor by SARS-CoV-2 Spike Protein in Human Placental Cells: Implications for SARS-CoV-2 Pathogenesis in Pregnant Women

Regulation of Proinflammatory Molecules and Tissue Factor by SARS-CoV-2 Spike Protein in Human Placental Cells: Implications for SARS-CoV-2 Pathogenesis in Pregnant Women

SARS-CoV-2 infects cells via binding to ACE2 and TMPRSS2, which allows the virus to fuse with host cells. The viral RNA is detected in the placenta of SARS-CoV-2-infected pregnant women and infection is associated with adverse pregnancy complications. Therefore, we hypothesize that SARS-CoV-2 infect...

Full description

Bibliographic Details
Main Authors: Xiaofang Guo, Nihan Semerci, Viviana De Assis, Umit A. Kayisli, Frederick Schatz, Thora S. Steffensen, Ozlem Guzeloglu-Kayisli, Charles J. Lockwood
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
ACE2
TMPRSS2
proinflammatory cytokines
tissue factor
trophoblast
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.876555/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.876555/full

Similar Items