Application of homozygosity haplotype analysis to genetic mapping with high-density SNP genotype data.

Application of homozygosity haplotype analysis to genetic mapping with high-density SNP genotype data.

BACKGROUND: In families segregating a monogenic genetic disorder with a single disease gene introduction, patients share a mutation-carrying chromosomal interval with identity-by-descent (IBD). Such a shared chromosomal interval or haplotype, surrounding the actual pathogenic mutation, is typically...

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Bibliographic Details
Main Authors: Haiyan Jiang, Andrew Orr, Duane L Guernsey, Johane Robitaille, Géraldine Asselin, Mark E Samuels, Marie-Pierre Dubé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2670504?pdf=render

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http://europepmc.org/articles/PMC2670504?pdf=render

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