mTORC2 Is Activated under Hypoxia and Could Support Chronic Myeloid Leukemia Stem Cells

mTORC2 Is Activated under Hypoxia and Could Support Chronic Myeloid Leukemia Stem Cells

Hypoxia is a critical condition that governs survival, self-renewal, quiescence, metabolic shift and refractoriness to leukemic stem cell (LSC) therapy. The present study aims to investigate the hypoxia-driven regulation of the mammalian Target of the Rapamycin-2 (mTORC2) complex to unravel it as a...

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Bibliographic Details
Main Authors: Cristina Panuzzo, Lucrezia Pironi, Alessandro Maglione, Simone Rocco, Serena Stanga, Chiara Riganti, Joanna Kopecka, Muhammad Shahzad Ali, Barbara Pergolizzi, Enrico Bracco, Daniela Cilloni
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
mTORC2 complex
phospho-Akt (Ser473)
leukemic stem cells
Rictor
TKI
Online Access:https://www.mdpi.com/1422-0067/24/2/1234

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https://www.mdpi.com/1422-0067/24/2/1234

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