Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.

Prolonged opening of the mitochondrial permeability transition pore (PTP) leads to cell death. Various ubiquinone analogs have been shown to regulate PTP opening but the outcome of PTP regulation by ubiquinone analogs on cell fate has not been studied yet.The effects of ubiquinone 0 (Ub(0)), ubiquin...

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Bibliographic Details
Main Authors: Flavien Devun, Ludivine Walter, Julie Belliere, Cécile Cottet-Rousselle, Xavier Leverve, Eric Fontaine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2909912?pdf=render