Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine

Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine

Abstract Base excision repair is the main pathway involved in active DNA demethylation. 5-formylcytosine and 5-carboxylcytosine, two oxidized moieties of methylated cytosine, are recognized and removed by thymine DNA glycosylase (TDG) to generate an abasic site. Using single molecule fluorescence ex...

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Bibliographic Details
Main Authors: Brittani L. Schnable, Matthew A. Schaich, Vera Roginskaya, Liam P. Leary, Tyler M. Weaver, Bret D. Freudenthal, Alexander C. Drohat, Bennett Van Houten
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53497-7

Internet

https://doi.org/10.1038/s41467-024-53497-7

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