Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids

Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids

Here we report the generation of nanobody dextran polymer conjugates (dextraknobs) that are loaded with small molecules, i.e., fluorophores or photosensitizers, for potential applications in cancer diagnostics and therapy. To this end, the molecules are conjugated to the dextran polymer which is cou...

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Bibliographic Details
Main Authors: Peter Bitsch, Eva S. Baum, Irati Beltrán Hernández, Sebastian Bitsch, Jakob Harwood, Sabrina Oliveira, Harald Kolmar
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
nanobodies
dextran
photosensitizer
tumor spheroid penetration
photodynamic therapy
Online Access:https://www.mdpi.com/1999-4923/15/10/2374

Internet

https://www.mdpi.com/1999-4923/15/10/2374

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