Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

The mammalian NF-κB p52:p52 homodimer together with its cofactor Bcl3 activates transcription of κB sites with a central G/C base pair (bp), while it is inactive toward κB sites with a central A/T bp. To understand the molecular basis for this unique property of p52, we have determined the crystal s...

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Bibliographic Details
Main Authors: Wenfei Pan, Vladimir A Meshcheryakov, Tianjie Li, Yi Wang, Gourisankar Ghosh, Vivien Ya-Fan Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
DNA conformation
NF-κB
crystal structure
MD simulation
transcriptional regulation
thermodynamics
Online Access:https://elifesciences.org/articles/86258

Internet

https://elifesciences.org/articles/86258

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