A randomized, double-blind study on the safety and immunogenicity of rTSST-1 variant vaccine: phase 2 resultsResearch in context

A randomized, double-blind study on the safety and immunogenicity of rTSST-1 variant vaccine: phase 2 resultsResearch in context

Summary: Background: Toxic shock syndrome toxin-1 (TSST-1) is a superantigen produced by Staphylococcus aureus that causes the life-threatening toxic shock syndrome. The development of a safe and immunogenic vaccine against TSST-1 remains an unmet medical need. We investigated the safety, tolerabil...

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Bibliographic Details
Main Authors: Christian Schoergenhofer, Georg Gelbenegger, Dzenita Hasanacevic, Léa Schöner, Margarete M. Steiner, Christa Firbas, Nina Buchtele, Ulla Derhaschnig, Andreas Tanzmann, Nina Model, Julian Larcher-Senn, Manuel Drost, Martha M. Eibl, Andreas Roetzer, Bernd Jilma
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:EClinicalMedicine
Subjects:
Staphylococcus aureus
Toxic shock syndrome
Superantigen
TSST-1
Vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023005813

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http://www.sciencedirect.com/science/article/pii/S2589537023005813

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