Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

Abstract Background Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of...

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Bibliographic Details
Main Authors: Yin Li, Yan Wang, Yong Zhou, Jie Li, Kai Chen, Leisi Zhang, Manman Deng, Suqi Deng, Peng Li, Bing Xu
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Clinical Epigenetics
Subjects:
Chidamide
Drug resistance
DNA damage
Acute myeloid leukemia
Leukemia stem and progenitor cells
Online Access:http://link.springer.com/article/10.1186/s13148-017-0377-8

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http://link.springer.com/article/10.1186/s13148-017-0377-8

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