Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D<sub>3</sub> and Identification of Their Metabolites

Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D<sub>3</sub> and Identification of Their Metabolites

Vitamin D<sub>3</sub> (<b>1</b>) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D<sub>3</sub> (<b>6a</b>) and 4β,25-dihydroxyvitamin D<sub>3</sub&g...

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Bibliographic Details
Main Authors: Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomolecules
Subjects:
vitamin D<sub>3</sub>
vitamin D<sub>3</sub> metabolites
4,25-dihydroxyvitamin D<sub>3</sub>
4,24,25-trihydroxyvitamin D<sub>3</sub>
Cytochrome P450
CYP3A4
Online Access:https://www.mdpi.com/2218-273X/13/7/1036

Internet

https://www.mdpi.com/2218-273X/13/7/1036

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