Different viral genes modulate virulence in model mammal hosts and Culex pipiens vector competence in Mediterranean basin lineage 1 West Nile virus strains

Different viral genes modulate virulence in model mammal hosts and Culex pipiens vector competence in Mediterranean basin lineage 1 West Nile virus strains

West Nile virus (WNV) is a single-stranded positive-sense RNA virus (+ssRNA) belonging to the genus Orthoflavivirus. Its enzootic cycle involves mosquito vectors, mainly Culex, and wild birds as reservoir hosts, while mammals, such as humans and equids, are incidental dead-end hosts. It was first di...

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Bibliographic Details
Main Authors: Lise Fiacre, Antoine Nougairède, Camille Migné, Maëlle Bayet, Maxime Cochin, Marine Dumarest, Teheipuaura Helle, Antoni Exbrayat, Nonito Pagès, Damien Vitour, Jennifer P. Richardson, Anna-Bella Failloux, Marie Vazeille, Emmanuel Albina, Sylvie Lecollinet, Gaëlle Gonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Microbiology
Subjects:
Culex pipiens
host virulence
Mediterranean basin
reverse genetics
vector competence
West Nile virus lineage 1
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1324069/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1324069/full

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