Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis

Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis

Background: Activation of protease-activated receptor-2 (PAR2) has been implicated in inflammation, pruritus, and skin barrier regulation, all characteristics of atopic dermatitis (AD), as well as Netherton syndrome which has similar characteristics. However, understanding the precise role of PAR2 o...

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Bibliographic Details
Main Authors: Timo Buhl, Akihiko Ikoma, Cordula Kempkes, Ferda Cevikbas, Mathias Sulk, Joerg Buddenkotte, Tasuku Akiyama, Debbie Crumrine, Eric Camerer, Earl Carstens, Michael P. Schön, Peter Elias, Shaun R. Coughlin, Martin Steinhoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
atopic dermatitis
protease-activated receptor-2
PAR2
endothelin
house dust mite
dorsal root ganglion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01740/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01740/full

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