Morphine Attenuates Apically-Directed Cytokine Secretion from Intestinal Epithelial Cells in Response to Enteric Pathogens

Morphine Attenuates Apically-Directed Cytokine Secretion from Intestinal Epithelial Cells in Response to Enteric Pathogens

Epithelial cells represent the first line of host immune defense at mucosal surfaces. Although opioids appear to increase host susceptibility to infection, no studies have examined opioid effects on epithelial immune functions. We tested the hypothesis that morphine alters vectorial cytokine secreti...

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Bibliographic Details
Main Authors: Amanda J. Brosnahan, Bryan J. Jones, Cheryl M. Dvorak, David R. Brown
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Pathogens
Subjects:
morphine
opioid receptors
small intestine
epithelial cell
Escherichia coli
Salmonella enterica
interleukin-6
interleukin-8
Toll-like receptors
swine
Online Access:http://www.mdpi.com/2076-0817/3/2/249

Internet

http://www.mdpi.com/2076-0817/3/2/249

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