Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening

MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate eIF4E at Ser209 to control the translation of certain mRNAs and regulate the process of cell proliferation, cell migration and invasion, etc. Development of MNK inhibitors would be an effective treatment for related di...

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Bibliographic Details
Main Authors: Xin Jin, Maowei Li, Tingting Qiu, Rilei Yu, Tao Jiang
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Marine Drugs
Subjects:
Online Access:https://www.mdpi.com/1660-3397/20/7/429