High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism

High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism

Abstract Background Aberrant tryptophan (Trp)-kynurenine (Kyn) metabolism has been implicated in the pathogenesis of human disease. In particular, populations with long-term western-style diets are characterized by an excess of Kyn in the plasma. Host-gut microbiota interactions are dominated by die...

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Bibliographic Details
Main Authors: Penghao Sun, Mengli Wang, Yong-Xin Liu, Luqi Li, Xuejun Chai, Wei Zheng, Shulin Chen, Xiaoyan Zhu, Shanting Zhao
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Microbiome
Subjects:
High-fat diet
Gut microbiota
Tryptophan metabolism
Kynurenine
Mitochondrial dysfunction
Online Access:https://doi.org/10.1186/s40168-023-01606-x

Internet

https://doi.org/10.1186/s40168-023-01606-x

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