Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study

Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study

Abstract Background Myelodysplastic syndrome (MDS) is a complicated hematopoietic malignancy characterized by bone marrow (BM) dysplasia with symptoms like anemia, neutropenia, or thrombocytopenia. MDS exhibits considerable heterogeneity in prognosis, with approximately 30% of patients progressing t...

Full description

Bibliographic Details
Main Authors: Xinyu Guo, Wenyan Jin, Yuchen Wen, Zhiqin Wang, Xiaotong Ren, Zhaoyun Liu, Rong Fu, Zhigang Cai, Lijuan Li
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Journal of Translational Medicine
Subjects:
Myelodysplastic syndrome
Single cell omics
Computational hematopoiesis
Bone marrow cell reference
HMGA1
Online Access:https://doi.org/10.1186/s12967-024-05496-x

Internet

https://doi.org/10.1186/s12967-024-05496-x

Similar Items