Hydroxyhexylitaconic acids as potent IMP-type metallo-β-lactamase inhibitors for controlling carbapenem resistance in Enterobacterales

Hydroxyhexylitaconic acids as potent IMP-type metallo-β-lactamase inhibitors for controlling carbapenem resistance in Enterobacterales

ABSTRACTMetallo-β-lactamases (MBLs) represent one of the main causes of carbapenem resistance in the order Enterobacterales. To combat MBL-producing carbapenem-resistant Enterobacterales, the development of MBL inhibitors can restore carbapenem efficacy for such resistant bacteria. Microbial natural...

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Bibliographic Details
Main Authors: Jun-ichi Wachino, Wanchun Jin, Chihiro Norizuki, Kouji Kimura, Motonori Tsuji, Hiromasa Kurosaki, Yoshichika Arakawa
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:Microbiology Spectrum
Subjects:
metallo-β-lactamase
Enterobacterales
inhibitors
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02344-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02344-23

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