Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects

Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects

Abstract Acute coronary syndromes, such as myocardial infarction (MI), lack effective therapies beyond heart transplantation, which is often hindered by donor scarcity and postoperative complications. Human induced pluripotent stem cells (hiPSCs) offer the possibility of myocardial regeneration by d...

Podrobná bibliografie
Hlavní autoři:	Xi Jiang, Xin Lian, Kun Wei, Jie Zhang, Kaihua Yu, Haoming Li, Haichun Ma, Yin Cai, Lei Pang
Médium:	Článek
Jazyk:	English
Vydáno:	BMC 2024-10-01
Edice:	Stem Cell Research & Therapy
Témata:	Acute coronary syndromes Myocardial infarction Induced pluripotent stem cells iPSC-cardiomyocytes Maturation Energy metabolism
On-line přístup:	https://doi.org/10.1186/s13287-024-03961-4

Podobné jednotky

Maturation of induced pluripotent stem cell-derived cardiomyocytes and its therapeutic effect on myocardial infarction in mouse
Autor: Peng Wu, a další
Vydáno: (2023-02-01)

Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling
Autor: Sofija Vučković, a další
Vydáno: (2022-07-01)

iPSC-Derived Cardiomyocytes in Inherited Cardiac Arrhythmias: Pathomechanistic Discovery and Drug Development
Autor: Eline Simons, a další
Vydáno: (2023-01-01)

Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells
Autor: Jiangtao Li, a další
Vydáno: (2022-06-01)

Metabolic Maturation Exaggerates Abnormal Calcium Handling in a <i>Lamp2</i> Knockout Human Pluripotent Stem Cell-Derived Cardiomyocyte Model of Danon Disease
Autor: Robert J. Barndt, a další
Vydáno: (2022-12-01)

Disease Modeling of Mitochondrial Cardiomyopathy Using Patient-Specific Induced Pluripotent Stem Cells
Autor: Takeshi Tokuyama, a další
Vydáno: (2021-09-01)

Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes
Autor: Francis Grafton, a další
Vydáno: (2021-08-01)

Cardiac repair in a murine model of myocardial infarction with human induced pluripotent stem cell-derived cardiomyocytes
Autor: Xin Jiang, a další
Vydáno: (2020-07-01)

Activation of AMPK Promotes Maturation of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
Autor: Liang Ye, a další
Vydáno: (2021-03-01)

Action potential variability in human pluripotent stem cell-derived cardiomyocytes obtained from healthy donors
Autor: A. B. Carvalho, a další
Vydáno: (2022-12-01)

The role and mechanism of NRG1/ErbB4 in inducing the differentiation of induced pluripotent stem cells into cardiomyocytes
Autor: Xiaoou Li, a další
Vydáno: (2024-10-01)

Strategies to improve the therapeutic effect of pluripotent stem cell-derived cardiomyocytes on myocardial infarction
Autor: Yang Xiao, a další
Vydáno: (2022-08-01)

Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes
Autor: Jingjun Zhou, a další
Vydáno: (2023-04-01)

Qualitative transcriptional signatures for evaluating the maturity degree of pluripotent stem cell-derived cardiomyocytes
Autor: Rou Chen, a další
Vydáno: (2019-03-01)

Immune cells and RBCs derived from human induced pluripotent stem cells: method, progress, prospective challenges
Autor: Jin-he Jiang, a další
Vydáno: (2024-01-01)

Impaired Relaxation in Induced Pluripotent Stem Cell‐Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy
Autor: Renjie Wang, a další
Vydáno: (2024-03-01)

Rock inhibitor may compromise human induced pluripotent stem cells for cardiac differentiation in 3D
Autor: Bin Jiang, a další
Vydáno: (2022-03-01)

In vitro maturation of human pluripotent stem cell-derived cardiomyocyte: A promising approach for cell therapy
Autor: Yun-Gwi Park, a další
Vydáno: (2022-06-01)

In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts
Autor: Shin Kadota, a další
Vydáno: (2017-02-01)

Unlocking the Pragmatic Potential of Regenerative Therapies in Heart Failure with Next-Generation Treatments
Autor: Yoshikazu Kishino, a další
Vydáno: (2023-03-01)

Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes
Autor: Yuichi Horikoshi, a další
Vydáno: (2019-09-01)

ELM2‐SANT Domain‐Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human‐Induced Pluripotent Stem Cells
Autor: Yu‐An Lu, a další
Vydáno: (2024-07-01)

Genetic and Pharmacological YAP Activation Induces Proliferation and Improves Survival in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Autor: Thuy Anh Bui, a další
Vydáno: (2023-08-01)

Recent advances in regulating the proliferation or maturation of human-induced pluripotent stem cell-derived cardiomyocytes
Autor: Hao Yang, a další
Vydáno: (2023-08-01)

Generation of an Alagille syndrome (ALGS) patient-derived induced pluripotent stem cell line (TRNDi032-A) carrying a heterozygous mutation (p.Cys682Leufs*7) in the JAG1 gene
Autor: Omer Hatim, a další
Vydáno: (2023-12-01)

Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling
Autor: Sherida de Leeuw, a další
Vydáno: (2019-07-01)

Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes
Autor: Hanbyeol Lee, a další
Vydáno: (2022-05-01)

iPSC-Derived Cardiomyocytes as a Disease Model to Understand the Biology of Congenital Heart Defects
Autor: Chithra K. Pushpan, a další
Vydáno: (2024-08-01)

Impact of Neurons on Patient-Derived Cardiomyocytes Using Organ-On-A-Chip and iPSC Biotechnologies
Autor: Albin A. Bernardin, a další
Vydáno: (2022-11-01)

Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes
Autor: Qianliang Yuan, a další
Vydáno: (2022-01-01)

Co-transplantation of Mesenchymal Stromal Cells and Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improves Cardiac Function After Myocardial Damage
Autor: Klaus Neef, a další
Vydáno: (2022-01-01)

How can we use stem cell-derived cardiomyocytes to understand the involvement of energetic metabolism in alterations of cardiac function?
Autor: Sabine Rebs, a další
Vydáno: (2023-09-01)

Do Human iPSC-Derived Cardiomyocytes Cultured on PLA Scaffolds Induce Expression of CD28/CTLA-4 by T Lymphocytes?
Autor: David Sergeevichev, a další
Vydáno: (2022-01-01)

Increasing the physical size and nucleation status of human pluripotent stem cell-derived ventricular cardiomyocytes by cell fusion
Autor: Chi-Wing Kong, a další
Vydáno: (2017-03-01)

Three-Dimensional Poly-(ε-Caprolactone) Nanofibrous Scaffolds Promote the Maturation of Human Pluripotent Stem Cells-Induced Cardiomyocytes
Autor: Mingming Zhang, a další
Vydáno: (2022-08-01)

Polymerized Laminin-521: A Feasible Substrate for Expanding Induced Pluripotent Stem Cells at a Low Protein Concentration
Autor: Fernanda C. P. Mesquita, a další
Vydáno: (2022-12-01)

Cardiac calcium regulation in human induced pluripotent stem cell cardiomyocytes: Implications for disease modeling and maturation
Autor: Patrick Ernst, a další
Vydáno: (2023-01-01)

Generation of two induced pluripotent stem cell lines from patients with cardiac amyloidosis carrying heterozygous transthyretin (TTR) mutation
Autor: Bernardo Bonilauri, a další
Vydáno: (2023-10-01)

Single-cell RNA sequencing reveals key regulators and differentiation trajectory of iPSC-derived cardiomyocytes
Autor: Lu Li, a další
Vydáno: (2024-11-01)

Exosomes From Induced Pluripotent Stem Cell–Derived Cardiomyocytes Promote Autophagy for Myocardial Repair
Autor: Michelle R. Santoso, a další
Vydáno: (2020-03-01)