LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions

LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions

Abstract Background To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals. Results The regulatory landscape around genes included both tissue-share...

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Bibliographic Details
Main Authors: Maša Roller, Ericca Stamper, Diego Villar, Osagie Izuogu, Fergal Martin, Aisling M. Redmond, Raghavendra Ramachanderan, Louise Harewood, Duncan T. Odom, Paul Flicek
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Genome Biology
Subjects:
Regulatory evolution
Gene regulation
Promoters
Enhancers
Transposable elements
Long Interspersed Nuclear Elements (LINEs)
Online Access:https://doi.org/10.1186/s13059-021-02260-y

Internet

https://doi.org/10.1186/s13059-021-02260-y

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