Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

Background: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture. Here, we demonstrate that CRC liver metastases o...

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Bibliographic Details
Main Authors: Jon N. Buzzelli, Djamila Ouaret, Graham Brown, Philip D. Allen, Ruth J. Muschel
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118300229

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http://www.sciencedirect.com/science/article/pii/S1873506118300229

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