Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy

Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy

Background: Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in the metabolism of tryptophan (TRP) to kynurenine (KYN). IDO1-dependent neurotoxic KYN metabolism plays a crucial role in the pathogenesis of many neurodegenerative disorders. However, the function of IDO1 in...

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Bibliographic Details
Main Authors: Ning Deng, Jiao Hu, Yu Hong, Yuewen Ding, Yifan Xiong, Zhiyong Wu, Wei Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
IDO1
epilepsy
kynurenine
tryptophan
inflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.638854/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.638854/full

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