Reduced Levels of H<sub>2</sub>S in Diabetes-Associated Osteoarthritis Are Linked to Hyperglycaemia, Nrf-2/HO-1 Signalling Downregulation and Chondrocyte Dysfunction

Reduced Levels of H<sub>2</sub>S in Diabetes-Associated Osteoarthritis Are Linked to Hyperglycaemia, Nrf-2/HO-1 Signalling Downregulation and Chondrocyte Dysfunction

Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the balance of hydrogen sulphide (H<sub>2</sub>S) are thought to play an important ro...

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Bibliographic Details
Main Authors: María Piñeiro-Ramil, Elena F. Burguera, Tamara Hermida-Gómez, Beatriz Caramés, Natividad Oreiro-Villar, Rosa Meijide-Faílde, Francisco J. Blanco, Carlos Vaamonde-García
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antioxidants
Subjects:
hydrogen sulphide
osteoarthritis
type 2 diabetes
chondrocytes
inflammation
nuclear factor-erythroid 2-related factor-2
Online Access:https://www.mdpi.com/2076-3921/11/4/628

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https://www.mdpi.com/2076-3921/11/4/628

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