TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4

TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4

TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an additional immune evasion function of this ba...

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Bibliographic Details
Main Authors: Qian Ou, Jia-qi Fang, Zhe-sheng Zhang, Zhe Chi, Jie Fang, Di-yan Xu, Kai-zhong Lu, Meng-qing Qian, Da-yong Zhang, Jun-ping Guo, Wei Gao, Na-ru Zhang, Jian-ping Pan
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23881-8

Internet

https://doi.org/10.1038/s41467-021-23881-8

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