TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4
TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an additional immune evasion function of this ba...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23881-8 |
| _version_ | 1818736043141103616 |
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| author | Qian Ou Jia-qi Fang Zhe-sheng Zhang Zhe Chi Jie Fang Di-yan Xu Kai-zhong Lu Meng-qing Qian Da-yong Zhang Jun-ping Guo Wei Gao Na-ru Zhang Jian-ping Pan |
| author_facet | Qian Ou Jia-qi Fang Zhe-sheng Zhang Zhe Chi Jie Fang Di-yan Xu Kai-zhong Lu Meng-qing Qian Da-yong Zhang Jun-ping Guo Wei Gao Na-ru Zhang Jian-ping Pan |
| author_sort | Qian Ou |
| collection | DOAJ |
| description | TcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an additional immune evasion function of this bacterially derived virulence factor. |
| first_indexed | 2024-12-18T00:30:52Z |
| format | Article |
| id | doaj.art-c5d2af311ed14389a1ad2c707549eaa0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:30:52Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c5d2af311ed14389a1ad2c707549eaa02022-12-21T21:27:09ZengNature PortfolioNature Communications2041-17232021-06-0112111410.1038/s41467-021-23881-8TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4Qian Ou0Jia-qi Fang1Zhe-sheng Zhang2Zhe Chi3Jie Fang4Di-yan Xu5Kai-zhong Lu6Meng-qing Qian7Da-yong Zhang8Jun-ping Guo9Wei Gao10Na-ru Zhang11Jian-ping Pan12Institute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeInstitute of Translational Medicine, Zhejiang University City CollegeTcpC is a well characterised multifunctional virulence factor expressed by uropathogenic Eschericia coli. Here the authors show that TcpC also targets neutrophil NETosis via its E3 ligase functionality promoting the degradation of PAD4, and represents an additional immune evasion function of this bacterially derived virulence factor.https://doi.org/10.1038/s41467-021-23881-8 |
| spellingShingle | Qian Ou Jia-qi Fang Zhe-sheng Zhang Zhe Chi Jie Fang Di-yan Xu Kai-zhong Lu Meng-qing Qian Da-yong Zhang Jun-ping Guo Wei Gao Na-ru Zhang Jian-ping Pan TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4 Nature Communications |
| title | TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4 |
| title_full | TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4 |
| title_fullStr | TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4 |
| title_full_unstemmed | TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4 |
| title_short | TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4 |
| title_sort | tcpc inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4 |
| url | https://doi.org/10.1038/s41467-021-23881-8 |
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