Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury

Extracellular matrix molecule chondroitin sulfate proteoglycans (CSPGs) are highly upregulated in scar tissues and form a potent chemical barrier for CNS axon regeneration. Recent studies support that the receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member leukocyte common antige...

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Bibliographic Details
Main Authors: Bin Xu, Dongsun Park, Yosuke Ohtake, Hui Li, Umar Hayat, Junjun Liu, Michael E. Selzer, Frank M. Longo, Shuxin Li
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
CSPG receptor
LAR phosphatase
Spinal cord injury
Scar inhibition
Axon regeneration
Functional recovery
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002617

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http://www.sciencedirect.com/science/article/pii/S0969996114002617

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