Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells.

Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells.

Marrow stromal cells (MSCs) isolated from mesenchymal tissues can propagate in vitro to some extent and differentiate into various tissue lineages to be used for cell-based therapies. Cellular senescence, which occurs readily in continual MSC culture, leads to loss of these characteristic properties...

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Main Authors: Masahiko Kanehira, Toshiaki Kikuchi, Shinya Ohkouchi, Taizou Shibahara, Naoki Tode, Arif Santoso, Hisayoshi Daito, Hiromitsu Ohta, Tsutomu Tamada, Toshihiro Nukiwa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281120?pdf=render

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http://europepmc.org/articles/PMC3281120?pdf=render

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