Analysis of innate and acquired resistance to anti-CD20 antibodies in malignant and nonmalignant B cells

The anti-CD20 monoclonal antibody, rituximab, provides a significant therapeutic benefit for patients with B-cell disorders. However, response to therapy varies and relapses are common, so an understanding of both inherited and acquired rituximab resistance is needed. In order to identify mechanisms...

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Bibliographic Details
Main Authors: George W. Small, Howard L. McLeod, Kristy L. Richards
Format: Article
Language:English
Published: PeerJ Inc. 2013-02-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/31.pdf