Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme that selectively neutralizes lipid hydroperoxides, and human gpx4 gen...

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Bibliographic Details
Main Authors: Lalage A. Katunga, Preeti Gudimella, Jimmy T. Efird, Scott Abernathy, Taylor A. Mattox, Cherese Beatty, Timothy M. Darden, Kathleen A. Thayne, Hazaim Alwair, Alan P. Kypson, Jitka A. Virag, Ethan J. Anderson
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Molecular Metabolism
Subjects:
Glutathione peroxidase 4
Lipid peroxidation
Obesity
Mitochondria
Inflammation
Human heart
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000629

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http://www.sciencedirect.com/science/article/pii/S2212877815000629

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