GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis

GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis

Abstract The serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of dysfunctional mitochondria, and defects in this process contribute to a variety of cardiometabolic and neurological diseases. A...

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Bibliographic Details
Main Authors: Qiang Zhu, Matthew E. Combs, Juan Liu, Xue Bai, Wenbo B. Wang, Laura E. Herring, Jiandong Liu, Jason W. Locasale, Dawn E. Bowles, Ryan T. Gross, Michelle Mendiola Pla, Christopher P. Mack, Joan M. Taylor
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43889-6

Internet

https://doi.org/10.1038/s41467-023-43889-6

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