Borrelia burgdorferi, the Lyme disease spirochete, possesses genetically-encoded responses to doxycycline, but not to amoxicillin.

Some species of bacteria respond to antibiotic stresses by altering their transcription profiles, in order to produce proteins that provide protection against the antibiotic. Understanding these compensatory mechanisms allows for informed treatment strategies, and could lead to the development of im...

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Bibliographic Details
Main Authors: Timothy C Saylor, Timothy Casselli, Kathryn G Lethbridge, Jessamyn P Moore, Katie M Owens, Catherine A Brissette, Wolfram R Zückert, Brian Stevenson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0274125